Joined May 2026
A senior NIH scientist and his research fellow were charged with smuggling vials of deactivated mpox virus into the country from Africa and lying about it.
A promising new study suggests rheumatoid arthritis may not be as inevitable as once thought for people at high risk. Researchers found that just one year of treatment with the immune-targeting drug abatacept delayed the onset of rheumatoid arthritis by up to four years, with benefits lasting long a…
A Salk Institute study found that a simple dietary amino acid, methionine, dramatically improved survival in mice facing severe infections and inflammatory conditions. Rather than directly targeting the immune system, methionine boosted kidney filtration, helping the body flush out excess inflammato…
Longevity startup NewLimit plans to launch its first clinical trial of a liver medicine after raising a staggering $435 million in new funding.
A surprising new study suggests that when it comes to pancreatic cancer, the kind of fat you eat may matter more than how much. Researchers found that oleic acid—the main fat in olive oil and several other common foods—sped up tumor growth in mice predisposed to pancreatic cancer, while omega-3-rich…
A long-overlooked organ may hold surprising clues to healthy aging and cancer survival. Researchers at Mass General Brigham used AI to analyze CT scans from tens of thousands of adults and found that people with healthier thymuses—a small immune-system organ once thought to become largely irrelevant…
As Legend’s LB2102 trial in SCLC fails to dazzle, co-developer Novartis banks on quick manufacturing to find a commercial edge.
At ASCO 2026, oral abstract presenters highlighted new and exciting central nervous system (CNS) tumour treatments.
Readouts in rare blood cancers like myelofibrosis, WM and CLL are attracting keen interest at this year’s ASCO conference.
Lilly’s $7bn acquisition of Kelonia seems to be bearing fruit, with other in vivo approaches showing promise at ASCO 2026.
Early data suggest KLN-1010, now acquired by Eli Lilly, could be more tolerable but less efficacious that AstraZeneca’s ESOT-01.
Abivax's ulcerative colitis data, Fulcrum's scrapped sickle cell drug, and more biotech news from The Readout
A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time. When NFIL3 was disabled, the cells remained stronger for longer and co…
A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year…
At ASCO 2026, Pfizer presented top line data for the Phase III TALAPRO-3 clinical trial, evaluating Talzenna combined with Xtandi.
Smart pharma is becoming reality. At PHARMAP 2026, industry leaders discussed the technologies transforming pharmaceutical production, supply-chain security and global healthcare delivery.
AstraZeneca has secured FDA approval for Imfinzi in combination with BCG induction and maintenance therapy for adults with BCG-naïve, high-risk NMIBC.
Both BMS and J&J touted positive data for their multiple myeloma drugs at ASCO 2026.
At ASCO 2026, companies debuted data that could hold the potential to disrupt the frontline treatment paradigm for various subtypes of NSCLC.
A number of companies presented new data on their cancer vaccine candidates at ASCO 2026.
The MIROVA miss dampens prospects for Elahere's near-term label expansion into platinum-sensitive disease.
The field is ecstatic about the prospect of a targeted therapy meaningfully extending overall survival in pancreatic cancer.
As the first-to-market DPP-1 inhibitor in the respiratory field, Brinsupri is on course to become the standard of care in bronchiectasis treatment.
Servier has signed an agreement to acquire Edgewise Therapeutics’ muscular dystrophy business in a deal valued at up to $2.65bn.
The FDA has accepted BMS' sNDA for Camzyos to treat adolescents aged 12 to under 18 years with symptomatic oHCM.
Lilly gave hospitals participating in a federal drug discount program five days to submit claims data or it will stop the price breaks
Medicaid work requirements, fast-tracked funding for experimental Ebola vaccines, and more health news from Morning Rounds
It’s time to rethink and redesign how patients enter the health care system altogether, writes emergency physician Iyesatta Massaquoi Emeli.
Growing legislative scrutiny across multiple states targets the corporate structure underlying most direct-to-consumer telehealth businesses.
States are racing to implement the new requirements by the start of next year.
Eli Lilly has told more than 1,000 hospitals participating in the 340B drug discount program to submit claims data over the next five days — or lose price breaks.
Abivax said its experimental treatment for ulcerative colitis showed significant efficacy in a closely watched trial, but shares of the company tanked on safety concerns.
With no licensed vaccines available to protect against the Ebola virus currently spreading in the Democratic Republic of the Congo, efforts are underway to fast-track development of at least three…
Here is some of what you may have missed from the world's largest cancer research meeting.
At the world's largest cancer research meeting, new data were plentiful. But this year, there was also a focus on grief.
The FDA has missed a self-imposed deadline to ban the use of electrical shock devices in people with intellectual disabilities.
We've been asking Medicare for weeks about the cost of giving seniors $50 obesity drugs.
Detailed study data for a pancreatic cancer treatment from Revolution Medicines confirmed it increased overall survival, from 13.2 months to 6.7 months
“You have to understand a person's belief if you want to address it,” Deva Sharma says on the “First Opinion Podcast” about requests for unvaccinated donor blood.
Eli Lilly announces two China deals, Akeso's lung cancer bispecific payoff, and more biotech news from The Readout
The Trump administration disregards infectious disease playbook, CEPI offers vaccine funding, and other health news from Morning Rounds
The French pharma firm Servier is buying an experimental muscular dystrophy drug from Edgewise Therapeutics for $1.55 billion upfront.
Older adults on Medicare can get Wegovy and Zepbound for $50 a month, starting in July. But the agency still is not sharing how much this will cost taxpayers.
A compound named “substance God help me” by its longtime champion could benefit from RFK Jr.'s favorable views on using peptides.
The arbitration process has protected patients but generated financial windfalls for some clinicians.
ASCO Day 3: A huge advance for pancreatic cancer, a let down for Akeso and Summit, and a new approach to immunotherapy.
Melanoma may not become steadily more dangerous with age as scientists once assumed. In a surprising discovery, researchers found that cancer spread was lowest in young mice, surged in middle-aged mice, and then dropped again in very old mice. The key appears to be a special type of immune cell that…
Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connect…
Low-dose, low-cost immunotherapies may help patients in poorer countries access high-tech cancer treatments.
Melanoma may not become steadily more dangerous with age as scientists once assumed. In a surprising discovery, researchers found that cancer spread was lowest in young mice, surged in middle-aged mice, and then dropped again in very old mice. The key appears to be a special type of immune cell that…
Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connect…
Low-dose, low-cost immunotherapies may help patients in poorer countries access high-tech cancer treatments.
By doing hormone therapy up front in prostate cancer cases, the hope was to shrink the relapse rate after surgery. Results were encouraging.
Much-awaited results at ASCO show that scientists have indeed found a way to drug a "greasy ball" involved in pancreatic cancer.
A lung cancer drug developed in China was a highlight of ASCO but doctors want to see follow-up in a more diverse population.
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Spending time with close companions might do more than strengthen bonds—it could also reshape your gut bacteria. In a study of island birds, those with stronger social ties shared more gut microbes, especially types that require direct contact to spread. This suggests that social interaction itself—…
Public restrooms might seem like a germ nightmare, but the real risks aren’t always where you think. While toilet seats can carry bacteria, viruses, and even parasite traces, studies show they’re often cleaner than high-touch surfaces like door handles and flush levers. The biggest hidden threat com…
A new study suggests fish oil may help reduce insulin resistance even in people who aren't obese. In diabetic rats, omega-3 supplementation improved blood sugar levels, cholesterol, and inflammation by shifting immune cells into a more anti-inflammatory mode.
Scientists have developed a new way to fight gum disease without wiping out the mouth’s helpful bacteria—a major shift from traditional treatments. Instead of killing everything, this targeted approach blocks only the harmful microbes that drive periodontitis, allowing beneficial bacteria to thrive …
A massive, nearly 20-year study tracking over 650,000 Americans with irritable bowel syndrome is raising new questions about the long-term safety of common treatments. Researchers found that some widely used medications—including antidepressants and certain antidiarrheal drugs—were linked to a small…
A surprising new clinical trial has revealed that metformin—a cheap, century-old drug widely used for type 2 diabetes—may help people with type 1 diabetes in an unexpected way. While researchers initially hoped it would reduce insulin resistance, they instead found it allows patients to use about 12…
Scientists have uncovered a surprising twist in how bacteria share genes—including those that spread antibiotic resistance. Tiny virus-like particles called gene transfer agents (GTAs), once ancient viral invaders, have been repurposed by bacteria into delivery systems that shuttle DNA between neigh…
A popular Korean skincare ingredient may be far more powerful than anyone realized. Scientists have discovered that madecassic acid—derived from the herb Centella asiatica—can stop antibiotic-resistant bacteria in their tracks, including dangerous strains of E. coli. By targeting a bacterial protein…
A trio of common amino acids may hold the key to unlocking far more powerful gene therapies. Researchers found that adding them to lipid nanoparticles can boost mRNA delivery up to 20-fold and push CRISPR editing efficiency close to 90%. The trick isn’t changing the drug—but helping cells take it in…
Scientists have discovered that combining two existing drugs can dramatically reduce liver fat linked to a common and often silent disease. The treatment not only improved liver health in animal models but also showed potential to lower heart-related risks. Interestingly, using lower doses of both d…
A newly discovered virus hiding inside a common gut bacterium could help explain one of medicine’s long-standing mysteries: why a microbe found in both healthy people and cancer patients is linked to colorectal cancer. The research suggests that the interaction between bacteria and the viruses they …
A new minimally invasive procedure may help people keep weight off after stopping popular drugs like Ozempic and semaglutide—something most patients struggle with. In a clinical trial, those who underwent a technique called duodenal mucosal resurfacing regained far less weight compared to others aft…
Scientists have uncovered how graphene oxide pulls off a remarkable trick: it hunts down and destroys harmful bacteria while leaving human cells completely unharmed. By targeting a molecule found only in bacterial membranes, this ultra-thin carbon-based material acts with laser-like precision—offeri…
A gut bacterium may be quietly fueling depression through an unexpected chemical twist. Researchers found that when Morganella morganii interacts with a common pollutant, it produces a molecule that triggers inflammation—something strongly linked to depression. This finding helps explain how gut mic…
Deep within the brain, scientists have uncovered a hidden “switch” that may decide whether pain fades away—or lingers for months or even years. Researchers found that a small, little-known region called the caudal granular insular cortex (CGIC) acts like a command center, telling the body to keep pa…
Researchers have found an enzyme that can turn fragile drug molecules into durable ring shapes. This could help medications like Ozempic last longer and work more effectively. The process is simpler and more precise than traditional methods, even for complex drugs. It may open the door to stronger, …
A decades-old drug once used to treat sleeping sickness is now showing surprising promise against an ultra-rare and life-threatening genetic disorder called Bachmann-Bupp syndrome (BABS). Early patient treatments suggest the drug, DFMO, may ease severe symptoms by targeting the underlying genetic ma…
A major review of 217 trials shows that aerobic exercise is the most effective option for managing knee osteoarthritis. Activities like walking, cycling, and swimming outperformed other exercise types in reducing pain and improving movement. While alternatives like strength training and mind-body ex…
Scientists have uncovered a surprising new layer of complexity in Cannabis, identifying dozens of previously unknown compounds—including the first-ever evidence of rare molecules called flavoalkaloids in its leaves. These compounds, prized for their potential health benefits, were hidden among a ric…
GLP-1 drugs like semaglutide—best known for treating diabetes and driving weight loss under the brand names Ozempic and Wegovy—may also deliver a surprising mental health boost. In a massive study tracking nearly 100,000 people over more than a decade, researchers found that these medications were l…
Creatine might be famous in the gym, but its real story is far more interesting. Naturally produced in the body, it helps power cells by rapidly regenerating ATP—the fuel that keeps muscles, the brain, and even the heart running during intense activity. Supplementing with creatine can boost short bu…
A new study suggests a surprisingly simple compound could help fight Alzheimer’s disease. Researchers found that arginine—an inexpensive amino acid already considered safe—can reduce the buildup of toxic amyloid proteins in the brain, a hallmark of the disease. In animal models, oral arginine not on…
GLP-1 weight-loss drugs like Ozempic and Wegovy are often celebrated as game-changing solutions—but new research reveals a surprising social twist. People who lose weight using these medications may actually face more judgment than those who lose weight through diet and exercise—or even those who do…
Scientists have developed a breakthrough injectable biomaterial that travels through the bloodstream to repair damaged tissue from within, reducing inflammation and jumpstarting healing. In animal studies, it successfully treated heart attack damage and even showed promise for conditions like trauma…
A major 10-year clinical trial is turning one of the world’s most common knee surgeries on its head. Researchers found that trimming a damaged meniscus—a procedure long believed to relieve pain—offers no real benefit over placebo surgery. Even more surprising, patients who had the operation actually…
A little-known tree from Brazil’s Atlantic Forest may hold a surprising weapon against COVID-19. Researchers discovered that compounds called galloylquinic acids, extracted from its leaves, can attack SARS-CoV-2 on multiple fronts—blocking the virus from entering cells, disrupting its replication, a…
Researchers have created a next-generation obesity drug that works like a “Trojan horse,” using GLP-1/GIP signals to slip a powerful metabolic enhancer directly into target cells. In mice, it outperformed existing treatments—curbing appetite, increasing weight loss, and improving blood sugar levels.…
Researchers have developed a stem cell-based model of the human intestine that may transform how new IBD treatments are discovered. After testing thousands of compounds, they identified glycyrrhizin — a natural substance found in black licorice — as a promising anti-inflammatory candidate. In both l…
Scientists have uncovered a surprising way to influence the bacteria living in our mouths — not by killing them, but by interrupting how they “talk” to each other. Researchers found that dental plaque bacteria use chemical signals to coordinate growth, and by blocking those signals, they were able t…
A common constipation drug may have unexpectedly unlocked a new way to slow chronic kidney disease — a condition that affects millions and often leads to dialysis. In a clinical trial involving 150 patients, researchers found that lubiprostone, a medication normally used to treat constipation, helpe…
ASCO, Day 2: promising news around lung cancer, new immunotherapies, and bold words from Rick Pazdur.
Scientists have uncovered a surprising secret hidden inside fat cells that could reshape how we think about obesity and metabolic disease. A protein called HSL, long believed to simply release stored fat when the body needs energy, turns out to have a second job deep inside the nucleus of fat cells—…
Researchers found a new way to kill harmful “zombie” cells that linger after chemotherapy and help cancers become more aggressive. These senescent cells survive by relying on a protective protein called GPX4, even while sitting on the edge of a deadly iron-triggered collapse. New drugs remove that p…
Scientists at McGill University have uncovered a hidden molecular “switch” that turns on a powerful calorie-burning system in brown fat — the body’s heat-generating fat linked to metabolism and weight control. The breakthrough centers on glycerol, a molecule released when fat is broken down in the c…
UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests. Scie…
A huge long-term study found that drinking two to three cups of coffee a day was linked to a much lower risk of dementia, especially before age 75. Researchers say caffeine may help keep brain cells active while reducing inflammation and harmful plaque buildup associated with Alzheimer’s disease. Bu…
Scientists at UBC Okanagan have uncovered how plants produce mitraphylline, a rare natural compound with promising anti cancer potential. The team identified two enzymes that work together to build the molecule’s unusual twisted structure, solving a mystery that had puzzled researchers for years. Be…
The US biotech’s technology integrates multiple protein modalities to simultaneously target a variety of disease mechanisms.
Japan’s pharmaceutical sector is gradually reorienting from deep, validation-led development towards execution-driven partnerships, as global pressure compresses timelines across drug development.
The shock to global trade risks triggering a sustained period of higher medical inflation while cost-of-living crises threaten healthcare affordability.
AbbVie’s ultra-rare blood cancer ADC secured FDA clearance while AstraZeneca’s oral SERD for breast cancer remains in regulatory limbo.
As the first psychedelics near approval, several other factors warrant attention to ensure effective and safe implementation.
Sanofi has received a priority review from the FDA for its NDA for venglustat, an oral GCSi intended for the treatment of type 3 GD3.
Learn how specialized logistics and end-to-end orchestration help ensure treatments arrive on time, on temperature, and fully compliant.
